GliSODin

• Superoxide is the anion O2⁻
• It is used by the immune system to kill invading microorganisms
• It is also produced in day-to-day metabolism as a by- product of the body's need for energy.
• Superoxide is highly toxic and from this one reactive oxygen species, numerous other toxic compounds can be generated such as the hydroxyl free-radical [OH], peroxynitrite [ONOO^−]  and hydrogen peroxide [H2O2].
• Without Superoxide Dismutase and enzyme designed to neutralize the superoxide anion, this molecule can cause immense damage at the cellular and molecular level.
• Superoxide dismutase is a vital antioxidant defence in nearly all cells exposed to oxygen - there are rare exceptions such as Lactobacillus plantarum and related lactobacilli,  these organisms use a different mechanism to neutralize the superoxide anion O2⁻.

Superoxide dismutase (SOD)

• It was noticed around the 1980's that some melons had shelf lives of around 15 days --- this was 3 - 4 times the shelf lives of other melons [cantaloupes].
• Extensive research was then undertaken to find out the mechanism behind these non-rotting melons. 
• What was found was that the melons that aged far less had much higher levels of SOD and catalase.
• Increasing SOD in the human body has been the holy grail for researchers over 40 years --- the problem has been that SOD itself is easily broken down in the stomach and so a mechanism to protect the SOD as it passed through the stomach to the small intestine was needed.
• The answer was to bind the SOD from these melons to a protein from wheat called gliadin a protein resistant to acid digestion. 

SOD and Longevity

• Humans produce an average of 90 micrograms per milliliter (mcg/ml) of SOD and live an average of nearly 80 years.
• Chimpanzees, produce 40 mcg/ml of SOD and on average live 40 years.
• Fruit flies have been genetically engineered to double their SOD levels than normal and research has shown these flies live twice as long as ordinary fruit flies.
• Research strongly suggests that SOD is a primary determinant of longevity in mammals^96,97. 

Synergy with Enduracell^TM

• GliSODin and Enduracell [Sulforaphane from Whole Broccoli Sprout Concentrate] work in synergy with each other. The increased superoxide dismutase [SOD] enzyme produced from GliSODin mops up reactive oxygen species [ROS] and the Enduracell [Sulforaphane] powerfully induces liver Phase II biotransformation enzymes^98,99 allowing this Phase II part of changing dangerous compounds in the liver to harmful ones, to keep pace with the liver's Phase I component [the Cytochrome P450 system]. If Phase II was sluggish, intermediate compounds produced by Phase I reactions [often more dangerous than the original compound], will accumulate to damage cells and tissues increasing your risk for chronic disease, inflammation and cancer.
• Please view the following QuickGuide: Sulforaphane