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Coeliac Disease

Gluten sensitivity

Coeliac Disease [US Celiac Disease]

Gluten sensitivity and the immune system

"Coeliac disease is one of the most under-diagnosed, yet most common chronic diseases. Left untreated, the possibility of severe consequences such as bowel cancer and osteoporosis increases.Coeliac disease affects approximately 1 in 100 people in Australia but 4 out of 5 people don't know they have it. Coeliac disease is an auto-immune disease, which means that the body produces antibodies that attack its own tissues. For people with coeliac disease, this is triggered by gluten, a protein found in wheat, rye, barley and oats." Coeliac Society of Australia.

In this tutorial, you will find out how a failed quest to create a cholera vaccine resulted in the discovery of a cholera produced zonula occludens toxin [Zot] that then led to the discovery of zonulin a protein designed to modulate the tight junctions [zonula occludens] allowing both small and large molecules and immune cells to pass through cell barriers into tissue spaces, the lymphatics and blood circulation.

Tight junction permeability or intestinal permeability also known as 'leaky gut' is a critical step towards the creation of many autoimmune diseases.

Please view the Coeliac Disease QuickGuide for more technical information about this important disease.

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