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Short Chain Fatty Acids & GPR43 Receptors

Dietary fermentable fibre & inflammation control

Diet and health

A solid indisputable link between diet-bowel-immune system regulation!

We now have a molecular explanation

“The immune system responds to pathogens by a variety of pattern recognition molecules such as the Toll-like receptors (TLRs), which promote recognition of dangerous foreign pathogens. However, recent evidence indicates that normal intestinal microbiota might also positively influence immune responses, and protect against the development of inflammatory diseases. One of these elements may be short-chain fatty acids (SCFAs), which are produced by fermentation of dietary fibre by intestinal microbiota. A feature of human ulcerative colitis and other colitic diseases is a change in ‘healthy’ microbiota such as Bifidobacterium and Bacteriodes, and a concurrent reduction in SCFAs.” [Maslowski et al 2009]

Science is making great inroads with regard to understanding the links between gastrointestinal tract microflora and human health.

Scientists at the Garvan Institute of Medical Research in Sydney, Australia have discovered an indisputable link between dietery fibre intake and immune system modulation through the GPR43 receptor on neutrophils and eosinophils. So what has been known to be the case through epidemiological studies in terms of fibre intake and health is now able to be conceptualized at the molecular level.

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