The Omega-6 EFAs are essentially pro-inflammatory and the Omega-3 EFAs are much less inflammatory to neutral. Omega-3's work by competing for the same enzymes that metabolize both these EFA groups thus consuming more Omega-3's will result in a dampening of the inflammatory response as more Omega-3 eicosanoids are produced and arachidonic acid is displaced from cell membranes.
The balance of Omega-6 to Omega-3's will ultimately determine systemic effects such as blood pressure, cardiovascular disease, immune responses, arthritic inflammation, worsening of asthma or COPD or bowel inflammatory disease.
Anti-inflammatory drugs such as aspirin or ibuprofen and tumeric [curcumin] act by downregulating eicosanoid synthesis.
DGLA and the action of the enzyme Delta-5-Desaturase [D5D] on DGLA is critical in deciding which series of eicosanoids will ultimately form --- inflammatory or anti-inflammatory.
This tutorial will take you step-by-step through this process simplifying this complex process for you.
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