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Modifying hormones & inducing liver enzymes

Glucosinolates from Brassica Vegetables

How glucosinolates affect hormone & liver metabolism

  • 'Glucosinolates (GLS) are a group of plant thioglucosides present in plants of Cruciferae family. They are well known for their toxic effects (mainly as goitrogens) in both man and animals at high doses. In contrast at subtoxic doses, their hydrolytic and metabolic products act as chemoprotective agents against chemically-induced carcinogens by blocking the initiation of tumours in a variety of rodent tissues, viz. liver, colon, mammary gland, pancreas, etc. They exhibit their effect by inducing Phase I and Phase II enzymes, inhibiting the enzyme activation, modifying the steroid hormone metabolism and protecting against oxidative damages. Acid condensation products (like DIM) are more effective than their parent compounds (like I3C).1'
  • Glucosinolates are responsible for the sharp, hot taste of wasabi, horseradish, mustard and other brassica vegetables. Glucosinolates are in fact natural pesticides that have been developed to protect the plant from toxic and harsh environments and this effect has a role in humans to help us protect ourselves from environmental noxious elements. 
  • The German Commission E [the German equivalent of the American FDA] approved horseradish as adjunctive treatment for Urinary Tract Infections [UTIs]2. Horseradish has about 10 times more glucosinolates than broccoli.
  • According to Cornell University's Department of Animal Science [Link Below]
    "Research indicates that glucosinolates and their derivatives may have potential in fighting human cancers. Inclusion of Brassica vegetables appear to help protect against rectal and colon cancer. These vegetables aid in the detoxification of carcinogens such as aflatoxins and polybromobiphenyl. They enhance the activity of several hepatic enzymes used in detoxification processes. Benzyl isothiocyanate and thiocyanate have been shown in the lab to inhibit tumor development in animals exposed to carcinogens. Indole-3- carbinol, a product of glucosinolates, is a compound with promise in anticancer research. "
  1. Das, S., A. Tyagi, et al. (2000). "Cancer modulation by glucosinolates: A review." Current Science 79(12): 1665-1671.
  2. Goodman, S. (2009). "Horseradish: Protection Against Cancer and More." Life Extension(November 2009): 89-92.
  3. Cornell University: Glucosinolates

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