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Monofunctional [Specific] inducer of Phase II Enzymes


Cellular protection through modulation of multiple targets

Sulforaphane is an isothiocyanate compound that is found in cruciferous vegetables such as broccoli, cabbage, bok choy, brussel's sprouts but is particularly rich in broccoli sprouts. Broccoli sprouts have the highest concentration of sulforaphane and in fact can contain 20 - 100 times more of the sulforaphane precursor glucoraphanin than the mature broccoli vegetable. The enzyme myrosinase transforms glucoraphanin (a glucosinolate) into sulforaphane upon damage to the plant (e.g. from chewing or cutting].

Sulforaphane has received a great deal of attention with regard to preventative health as it is described as having the ability to 'simultaneously modulate multiple targets involved in cellular protection.'

It also has immunomodulatory effects by interfereing with the action of NF-kB and thus modifying the inflammatory process by inhibiting the release of proinflammatory cytokines.

Sulforaphane is a potent inducer of Phase II enzymes and has great synergies with nutraceuticals such as GliSODin which has been developed to stimulate the production of Superoxide Dismutase [SOD]

The following tutorial looks at the mechanism of action of sulforaphane in protecting cells and preventing disease.

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